A facile one-pot synthetic method has been developed for constructing 6- oxa -spiro[4.5]decane skeletons by merging the ring-opening of benzo[ c ]oxepines and formal 1,2-oxygen migration reactions. More than 30 examples of the 6- oxa -spiro[4.5]decane derivatives have been synthesized under transition-metal-free conditions.
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Du et al. (2024) studied this question.
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