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The aim is to evaluate the effectiveness of oral baricitinib combined with NB-UVB phototherapy in treating generalized vitiligo.

Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy

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The aim is to evaluate the effectiveness of oral baricitinib combined with NB-UVB phototherapy in treating generalized vitiligo.
Treatment involved 2 patients with generalized vitiligo using oral baricitinib and NB-UVB phototherapy.
Assessment focused on skin repigmentation and patient response.
JAK-STAT signaling pathway inhibition was a key mechanism of action.
Both patients experienced excellent repigmentation of the affected skin areas.
Significant improvement in skin color observed after treatment, demonstrating efficacy in refractory cases.

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Randomized trial shows improved skin color in patients with vitiligo, suggesting a promising treatment option.

Li et al. (2023) studied this question.

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