Key result
Physalis angulata L. extract significantly decreased mRNA expression of Nox4 (p=0.000), Mmp8 (p=0.002), and Klf4 (p=0.007) in a Bleomycin-induced mouse model of lung fibrosis.
Why the study?
To explore the potential therapeutic effects of Physalis angulata L. (Ciplukan) extract on lung fibrosis resolution and related gene expressions in a bleomycin-induced mouse model.
Does Physalis angulata L. extract improve fibrosis-related gene expressions in a bleomycin-induced mouse model of lung fibrosis?
Does Physalis angulata L. extract improve fibrosis-related gene expressions in a bleomycin-induced mouse model of lung fibrosis?
p-value: p=0.000 for Nox4, 0.002 for Mmp8, 0.007 for Klf4
Physalis angulata L. extract demonstrates potential antifibrotic effects by downregulating Nox4, Mmp8, and Klf4 gene expressions in a mouse model of lung fibrosis.
Ciplukan may modulate fibrosis genes in bleomycin models; leaves open any role in human pulmonary fibrosis.
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Imaduddin et al. (2024) studied Lung fibrosis. Physalis angulata L. (Ciplukan) extract was evaluated on mRNA expression of Nox4, Klf4, Mmp8, and FAS (p=0.000 for Nox4, 0.002 for Mmp8, 0.007 for Klf4). Physalis angulata L. extract significantly decreased mRNA expression of Nox4 (p=0.000), Mmp8 (p=0.002), and Klf4 (p=0.007) in a Bleomycin-induced mouse model of lung fibrosis.
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