Key result
Among pregnant women with PAH-CHD, overall maternal mortality was 5.8%, with the highest mortality observed in those with Eisenmenger syndrome (23.3%) compared to left-to-right shunt PAH (1.4%).
Why the study?
Pulmonary arterial hypertension associated with congenital heart disease may increase maternal and fetal risk, prompting an evaluation of pregnancy outcomes in Chinese women with the condition.
Population
260 pregnant women with PAH-CHD in Beijing, China
Design
Retrospective study
Follow-up
Mean period of 5.9 ± 2.7 years
Authors
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Elevated maternal mortality and HF rates in PAH-CHD pregnancies warrant expert preconception counseling; extends risk estimates but leaves optimal strategies open.
Cohort (n=260)
No
Absolute Event Rate: 23.3% vs 1.4%
p-value: p=<0.001
Pregnancy in women with PAH-CHD carries significant maternal and fetal risks, including a 5.8% maternal mortality rate, highlighting the need for individualized risk-based management.
Liu et al. (2022) conducted a cohort in Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) in pregnancy (n=260). Eisenmenger syndrome (ES-PAH) vs. Left-to-right shunt PAH (L-R-PAH) was evaluated on Maternal death (p=<0.001). Among pregnant women with PAH-CHD, overall maternal mortality was 5.8%, with the highest mortality observed in those with Eisenmenger syndrome (23.3%) compared to left-to-right shunt PAH (1.4%).
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