Key result
In women with PAH-CHD, pregnancy resulted in a 36.2% rate of maternal death, severe heart failure, or pulmonary hypertensive crisis, with Eisenmenger syndrome as a predictor (P<0.001).
Why the study?
Pulmonary arterial hypertension is a severe complication in patients with congenital heart disease that poses a significant risk to women wishing to become pregnant.
Population
93 pregnant women (94 pregnancies) with PAH-CHD admitted for delivery in a tertiary center
Design
Single-center observational cohort study
Follow-up
Peripartum period
Authors
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High peripartum risks persist in PAH-CHD; reinforces contraindication and leaves open optimal multidisciplinary strategies.
Cohort (n=93)
No
Maternal mortality and morbidity remain high (36.2% composite complication rate) in pregnant women with PAH-CHD, particularly those with Eisenmenger syndrome or repaired defects.
Li et al. (2019) conducted a cohort in Pulmonary arterial hypertension related to congenital heart disease (PAH-CHD) (n=93). Pregnancy was evaluated on Combined endpoint of maternal death, severe heart failure requiring treatment, or pulmonary hypertensive crisis. In women with PAH-CHD, pregnancy resulted in a 36.2% rate of maternal death, severe heart failure, or pulmonary hypertensive crisis, with Eisenmenger syndrome as a predictor (P<0.001).
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