Key result
Management of sepsis in pulmonary hypertension requires balancing competing demands from the left and right heart, utilizing judicious intravenous fluids and early initiation of vasopressors.
Why the study?
Pulmonary hypertension can create competing circulatory demands during sepsis and septic shock, making evaluation and management challenging.
What are the key factors to consider in the evaluation and management of patients with pulmonary hypertension who develop sepsis?
What are the key factors to consider in the evaluation and management of patients with pulmonary hypertension who develop sepsis?
This review highlights the complex challenges and considerations in managing sepsis in patients with pulmonary hypertension, focusing on hemodynamic stability and the continuation or transition of specific therapies.
Requires careful titration of PH therapies in sepsis; leaves open optimal protocols for prospective trials.
Pulmonary hypertension, characterized by elevated pressures in the pulmonary arteries leading to abnormalities in right ventricular function, may lead to competing demands between the pulmonary and systemic circulation during sepsis and septic shock. As a result, management of pulmonary hypertension in sepsis, including identifying the source of infection, maintaining hemodynamic stability and continuing or transitioning pulmonary hypertension-specific therapies can often be challenging. The goal of this review is to highlight factors to consider in the evaluation and management of patients with pulmonary hypertension and sepsis.
No takes yet. Share an insight, caveat, or question.
Prohaska et al. (2025) conducted a review in Pulmonary hypertension and sepsis. Management of sepsis in pulmonary hypertension requires balancing competing demands from the left and right heart, utilizing judicious intravenous fluids and early initiation of vasopressors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: