Evaluation of exacerbations and blood eosinophils in UK and US COPD populations

Claus Vogelmeier; Κonstantinos Κostikas; Juanzhi Fang; Huichuan Tian; Bethan Jones; Christopher Ll. Morgan; Robert Fogel; F Gutzwiller; Hui Cao

doi:10.1186/s12931-019-1130-y

August 7, 2019Respiratory ResearchOpen Access

Evaluation of exacerbations and blood eosinophils in UK and US COPD populations

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Key Points

This research aims to evaluate the relationship between exacerbation frequency and blood eosinophil levels in COPD patients from the UK and US.
Retrospective cohort analysis using UK Clinical Practice Research Datalink (CPRD) and US Optum Clinformatics Data Mart databases.
Examined 15,364 UK patients and 139,465 US patients meeting eligibility criteria.
Analyzed the frequency of exacerbations and blood eosinophil distributions over two years.
In CPRD, 82.8% of patients with ≥2 exacerbations had at least one exacerbation during the follow-up year, compared to 80.6% in Optum.
Approximately 17.0% of COPD patients in CPRD and 13.3% in Optum had eosinophil counts ≥400 cells/μL.
10% of COPD patients had both ≥2 exacerbations and eosinophil counts ≥300 cells/μL across both databases.

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Implication

Retrospective cohort analysis shows high variability in blood eosinophil counts in COPD populations from the UK and US, indicating treatment considerations.

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Vogelmeier et al. (2019) studied this question.

synapsesocial.com/papers/6a61746a0ad10d77180a39b4 https://doi.org/10.1186/s12931-019-1130-y

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Evaluation of exacerbations and blood eosinophils in UK and US COPD populations

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Discussion

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Evaluation of exacerbations and blood eosinophils in UK and US COPD populations

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