Genome‐Wide Association Study of Atrial Fibrillation Recurrence After Radiofrequency Catheter Ablation in a Japanese Population

Figures

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  Figure 1. Forest plot of the clinical information analysis. The blue bars indicate a false discovery rate (FDR) of 0.05 or greater, whereas the red bars indicate an FDR of < 0.05. The error bars correspond to the 95% confidence intervals.

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  Figure 2. GWAS of atrial fibrillation recurrence. (a) Quantile–quantile plot of the genome‐wide p values. λ GC = 1.01. (b) Manhattan plot of the GWAS results. A p value of 5 × 10−6 indicated by the blue line was set as the threshold for association. The red arrows indicate six variants with a GWAS‐level suggestive significance (rs2106865, rs12577119, rs12574466, rs4902609, rs8027532, and rs2032303). GWAS, genome‐wide association study.

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  Figure 3. Forest plot of the association between the clinical information and candidate SNPs. The blue bars indicate a false discovery rate (FDR) of 0.05 or greater, whereas the red bars indicate an FDR of < 0.05. The error bars correspond to the 95% confidence intervals. * represents logistic regression adjusted for age and sex. † represents linear regression adjusted for age and sex. SNP, single nucleotide polymorphism; LA, left atrium.

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  Figure 4. Kaplan–Meier curves for AF recurrence in patients stratified for the ABCC8 variant rs2106865. p = 1.30 × 10−5 by log‐rank test, hazard ratio 1.74 (95% confidence interval 1.38–2.20).

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  Central illustration 1. This study aimed to identify the factors associated with atrial fibrillation (AF) recurrence after catheter ablation. The clinical information analysis revealed persistent AF, nonpulmonary AF triggers, NT‐proBNP levels, and the left atrial volume were clinical predictors of recurrence. A genome‐wide association study showed that six genetic variants were suggestively associated with AF recurrence. Notably, rs2106865 is linked to the ABCC8 expression in cardiac tissue and left atrial volume before ablation. The Cox model indicated an association between rs2106865 and the risk of AF recurrence (p = 1.30 × 10−5, HR 1.74). These findings may inform strategies to reduce AF recurrence and improve patient outcomes.