Fit Is It for Longevity Across Populations
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“CRF may be perhaps one of the most important risk factors (or 'risk marker') for cardiovascular disease and overall prognosis, as patients with a major CVD risk factor but with relatively high levels of CRF generally have a better prognosis than patients without that risk factor but with low CRF.”
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Lavie et al. (2022) studied this question.