Key result
Surface modifications with heparin, taurine, or aminosilane increased the in vitro fatigue durability of polyurethane heart valves, whereas polyethylene oxide modification was detrimental.
Why the study?
Do surface modifications (heparin, taurine, aminosilane, PEO) improve the in vitro fatigue durability and calcification resistance of polyurethane heart valves?
Do surface modifications (heparin, taurine, aminosilane, PEO) improve the in vitro fatigue durability and calcification resistance of polyurethane heart valves?
Specific surface modifications such as heparin, taurine, and aminosilane can enhance the fatigue durability of polyurethane heart valves without adversely affecting hydrodynamic function.
These modifications merit in vivo validation; leaves open durability benefits in clinical valve use.
Polyurethane heart valves can be functionally durable with minimal calcification, in vitro. In vivo, these characteristics will depend on the resistance of the polyurethane to thrombogenesis and biodegradation. Surface modification may improve the polyurethane in these respects, but may adversely affect calcification and durability. This study investigates the effects of surface modifications of two polyurethane heart valves (PEU and PEUE) on their in vitro fatigue and calcification behaviour. Modifications included heparin, taurine, 3-aminopropyltriethoxysilane and polyethylene oxide (PEO). Neither hydrodynamic function nor leaflet thickness distribution was significantly altered by surface modification. PEO-modification was detrimental to valve fatigue durability and calcification. Heparin, taurine or aminosilane modifications of PEU valves increased durability. Aminosilane modification of PEUE valves increased durability compared with PEO modification. Appropriate surface modification may be useful to improve blood compatibility of implantable polyurethanes, and may also be advantageous as regards fatigue durability of flexing materials in longterm applications.
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Bernacca et al. (1998) studied Polyurethane heart valves. Surface modifications (heparin, taurine, 3-aminopropyltriethoxysilane, polyethylene oxide) vs. Unmodified valves or other modifications was evaluated on In vitro fatigue durability and calcification behaviour. Surface modifications with heparin, taurine, or aminosilane increased the in vitro fatigue durability of polyurethane heart valves, whereas polyethylene oxide modification was detrimental.
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