Key result
From 1990 to 2021, the global age-standardized incidence rate of maternal hypertensive disorder decreased from 274.11 to 227.96 per 100,000, despite an increase in absolute case numbers.
Why the study?
Maternal hypertensive disorder threatens maternal and neonatal health, but existing burden studies have limitations such as limited data periods or lack of focus.
Observational
The global burden of maternal hypertensive disorders has decreased from 1990 to 2021, though significant regional disparities remain, with higher burdens in low-Socio-Development Index regions.
Disparities persist in low-SDI regions despite global declines; leaves open targeted strategies to close gaps.
BACKGROUND: Maternal hypertensive disorder seriously threatens maternal and neonatal health, contributing to high morbidity and mortality globally. Existing studies on its burden have limitations, like limited data periods or a lack of focus. There's a need for a comprehensive analysis. METHODS: This study utilized GBD 2021 data to systematically evaluate the global, regional, and national burden of Maternal hypertensive disorder from 1990 to 2021. It assessed deaths and Disability-Adjusted Life Years, explored temporal trends with linear regression, analyzed regional patterns via cluster analysis, identified burden change drivers using decomposition analysis, estimated achievable outcomes through frontier analysis, and predicted future trends with the Bayesian model for age-period-cohort for better public health planning. RESULTS: From 1990 to 2021, the global age-standardized incidence, prevalence, mortality, and Disability-Adjusted Life Years rates of Maternal hypertensive disorder decreased to 227.96,44.42,0.48, and 31.29 per 100,000, respectively. Based on Bayesian model for the age-period-cohort projections, they will continue to decline to 2046. However, there were marked disparities. Low-Socio-Development Index regions had a heavier burden, and some regions like parts of Latin America & Caribbean saw an increase, while East Asia had a decrease. Aging, population growth, and epidemiological changes had different effects on the burden across regions. CONCLUSIONS: This study suggests that targeted public health policies are essential. Low-income regions must enhance healthcare infrastructure and promote family planning, while high-income areas should focus on the aging maternal population. However, the study has limitations concerning data accuracy and model assumptions. Future research should strive to improve data quality and analytical models to better address maternal health disparities and enhance maternal health outcomes.
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Hu et al. (2025) conducted an observational in Maternal hypertensive disorder. Maternal hypertensive disorder vs. 1990 baseline was evaluated on Age-standardized incidence rate (ASIR) per 100,000. From 1990 to 2021, the global age-standardized incidence rate of maternal hypertensive disorder decreased from 274.11 to 227.96 per 100,000, despite an increase in absolute case numbers.
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