Solid-Phase Syntheses of Peptoids using Fmoc-ProtectedN-Substituted Glycines: The Synthesis of (Retro)Peptoids of Leu-Enkephalin and Substance P

Solid-phase synthesis of oligomeric peptoids can be conveniently achieved by a repetitive cycle consisting of 1) the removal of the Fmoc group and 2) coupling of a N-substituted glycine derivative (a peptoid monomer). This “monomer” method allows the monitored synthesis of relatively large quantities of pure peptoids as well as the translation of in principle any peptide into the corresponding peptoid, illustrated here (below) by the solid-phase synthesis on a peptide synthesizer of the peptoid of substance P.