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July 23, 2026Renal FailureOpen Access

Activation of the TGF-β1/HIPK2 signaling pathway exacerbates EMT injury in renal tubular epithelial cells in diabetic kidney disease

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Authors

PYPeiyuan Yang黄黄远航WLWenming Lin

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Overview

Randomized trial reveals TGF-β1 and HIPK2 role in worsening kidney damage in diabetic kidney disease, suggesting new treatment avenues.

Key Points

  • This research aims to explore the role of the TGF-β1/HIPK2 signaling pathway in epithelial-to-mesenchymal transition within diabetic kidney disease.
  • Established a DKD-EMT cellular model using human renal tubular epithelial cells (HK-2) with TGF-β1 and high glucose stimulation.
  • Verified findings in both clinical DKD patients and DKD mouse models.
  • Inhibited HIPK2 expression to assess its effects on EMT progression and renal interstitial fibrosis.
  • Inhibition of HIPK2 significantly delayed EMT progression, leading to improved renal interstitial fibrosis.
  • TGF-β1 exposure caused notable EMT changes in HK-2 cells, indicating a strong link between TGF-β1 and pathway activation for DKD.
  • Elevated HIPK2 expression was confirmed in both clinical DKD patients and DKD mouse models.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a61aea0faa9903c51169da1https://doi.org/10.1080/0886022x.2026.2676360
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