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July 23, 2026Brain Communications0 citationsOpen Access

Molecular Insight Into Physical Activity's Role in Dementia Risk Through Plasma Proteomics

Plasma proteomics reveals molecular overlap between physical activity and dementia risk

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Authors

RSRowan SalonerEPEmily W. PaolilloAVAnna M. VandeBunte

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Overview

Randomized trial reveals biological markers linked to physical activity and dementia risk in older adults, suggesting preventive strategies.

Key Points

  • This research aims to uncover molecular pathways linking physical activity to reduced dementia risk in older adults.
  • Analyzed large-scale plasma proteomics data using SomaScan 7k across three cohorts: n=65 (objective PA), n=10,644 (self-reported PA), and n=654 (intervention).
  • Utilized differential regression and weighted gene co-expression network analysis to study protein correlates of physical activity and cognitive function.
  • Examined PA-related protein levels in cohorts with symptomatic Alzheimer’s disease and other dementias.
  • Identified PA-related plasma proteomic signatures linked to cell adhesion, immune response, and lipid metabolism.
  • Module M12 proteins showed positive associations with physical activity and cognitive function, and negative associations with Alzheimer’s, Parkinson’s, and FTD.
  • ANTXR2 levels predicted cognitive decline and related brain tissue proteomic signatures.

Cite This Study

Saloner et al. (2026) studied this question.

synapsesocial.com/papers/6a61af2ffaa9903c5116a16fhttps://doi.org/10.1093/braincomms/fcag287
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