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July 23, 2026Nature CommunicationsOpen Access

Towards a proteomic plasma biomarker panel for diagnosing vasculitis remission

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Authors

UJUwe JerkeMKMarieluise KirchnerTBTheda UP Bartolomaeus

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Overview

Randomized trial identifies a 7-protein panel for diagnosing remission in ANCA-associated vasculitis, indicating potential for improved treatment decisions.

Key Points

  • This research aims to identify plasma biomarkers that reliably indicate remission in patients with ANCA-associated vasculitis.
  • Employed a two-tiered proteomics strategy combining global discovery and targeted validation.
  • Developed a 7-protein panel implemented in a mass spectrometry-based assay.
  • Conducted confirmatory tests in an independent patient cohort.
  • The 7-protein panel significantly outperformed traditional biomarkers like C-reactive protein in diagnostic performance.
  • The diagnostic accuracy of the panel indicates a reliable method for determining remission in AAV patients.
  • Findings suggest potential for reduced treatment-related burden and lower healthcare costs.

Cite This Study

Jerke et al. (2026) studied this question.

synapsesocial.com/papers/6a61b02ffaa9903c5116addfhttps://doi.org/10.1038/s41467-026-75755-6
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Also Consider

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  1. 1Large-scale proteome profiling identifies circulating biomarkers for disease activity and organ involvement in ANCA-associated vasculitides2026
  2. 2OP0109 SERUM PROTEOMIC PROFILING IN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY ASSOCIATED VASCULITIS (AAV)2024
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