Key result
High-dose vitamin C during bilateral total knee replacement lowered malondialdehyde and Troponin I levels and improved arterial oxygen tension and mean blood pressure compared to controls.
Why the study?
Does high-dose intravenous vitamin C reduce oxygen free radical production and myocardial injury in elderly patients undergoing bilateral total knee replacement with tourniquet ischaemia-reperfusion?
Does high-dose intravenous vitamin C reduce oxygen free radical production and myocardial injury in elderly patients undergoing bilateral total knee replacement with tourniquet ischaemia-reperfusion?
High-dose intravenous vitamin C during bilateral total knee replacement may protect the myocardium by reducing oxygen free radical production and ischemia-reperfusion injury.
Answers are grounded in this paper and cite their sources.
High-dose vitamin C may mitigate oxidative stress in TKR; small Level 5 study leaves open clinical benefit and requires larger trials.
This study investigated the effects of high-dose vitamin C on oxygen free radical production and cardiac enzymes after tourniquet application and ischaemia-reperfusion injury during bilateral total knee replacement (TKR) in elderly patients. In the vitamin C (VC) group (VC group, n = 16), during surgery, patients received a priming bolus of 0.06 g/kg vitamin C with 100 ml saline followed by 0.02 g/kg vitamin C mixed with 30 ml saline, intravenously. The control group (n = 16) received no intra-operative vitamin C. In the VC group, malondialdehyde levels were lower, and arterial oxygen tension and mean blood pressure were higher, than in controls after post-operative deflation of both knee tourniquets. Troponin I levels were lower in the VC group than in controls 8 h post-operation. Administering high-dose vitamin C during bilateral TKR could prevent oxygen free radical production and a decline in arterial oxygen tension and mean blood pressure induced by ischaemia-reperfusion injury, thereby protecting the myocardium.
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Lee et al. (2010) studied Tourniquet ischaemia-reperfusion injury during bilateral total knee replacement (n=32). High-dose vitamin C vs. No intra-operative vitamin C was evaluated on Malondialdehyde levels, arterial oxygen tension, mean blood pressure, and Troponin I levels. High-dose vitamin C during bilateral total knee replacement lowered malondialdehyde and Troponin I levels and improved arterial oxygen tension and mean blood pressure compared to controls.
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