Key result
In conscious sheep, cardiac sympathetic nerve activity decreased gradually from 78 bursts/min at baseline to 60 bursts/min on day 5 post-surgery (P=0.02) and stabilized thereafter.
Continual recording of cardiac sympathetic nerve activity in conscious sheep is feasible and demonstrates a decrease and stabilization of activity during the first week postsurgery, providing a valuable model for studying cardiac disease.
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New ovine method enables chronic CSNA recording; leaves open human translation and clinical relevance.
Cardiac sympathetic nerve activity (CSNA) is of major importance in the etiology of heart disease but is impossible to measure directly in humans. Ovine and human cardiovascular systems are similar; therefore, we have developed a method for the daily recording of CSNA in conscious sheep. After thoracotomy, electrodes were glued into the left thoracic cardiac nerve and CSNA, blood pressure (BP), and heart rate were recorded daily. Satisfactory recordings > or =7 days of CSNA were obtained in 11 of 28 sheep (40%), mean recording time 10.6 days, range 7-47. During the first week, CSNA decreased gradually from 78 +/- 8 at baseline to 60 +/- 7 bursts/min on day 5 (P = 0.02) or from 76 +/- 9 to 57 +/- 7 bursts/100 beats on day 7 (P = 0.04). Similarly, BP decreased from 103 +/- 4 to 94 +/- 4 mmHg (P = 0.03). Low-frequency heart rate variability decreased from 0.12 +/- 0.02 to 0.06 +/- 0.02 ms(2) on day 6 (P = 0.004) but was not correlated to CSNA. In conclusion, CSNA that can be continually recorded in conscious sheep decreases during the first week postsurgery and, thereafter, stabilizes. This model should provide valuable insights in future investigations of cardiac disease.
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Jardine et al. (2002) studied Animal model for cardiac sympathetic nerve activity (n=28). Thoracotomy and electrode implantation for CSNA recording vs. Baseline was evaluated on Cardiac sympathetic nerve activity (CSNA) bursts/min (p=0.02). In conscious sheep, cardiac sympathetic nerve activity decreased gradually from 78 bursts/min at baseline to 60 bursts/min on day 5 post-surgery (P=0.02) and stabilized thereafter.
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