Key result
In anaesthetized dogs, coronary artery ligation induces renal vasodilation, which is prevented by atropine pretreatment, suggesting inhibition of cholinergic renal vasodilatation.
Why the study?
Does pretreatment with methylprednisolone succinate or atropine alter renal vasodilation in response to coronary artery ligation in anaesthetized dogs?
Does pretreatment with methylprednisolone succinate or atropine alter renal vasodilation in response to coronary artery ligation in anaesthetized dogs?
In a canine model, coronary artery ligation induces cholinergic renal vasodilation that maintains renal blood flow despite a drop in arterial blood pressure, an effect inhibited by atropine.
Highlights potential autonomic and steroid effects on renal flow post-coronary ligation in dogs; leaves open human cardiorenal relevance.
The effects of coronary artery ligation on renal vascular resistance were determined with and without pretreatment with methylprednisolone succinate or atropine in anaesthetized dogs. 2. With coronary artery ligation alone renal blood flow is maintained constant in spite of a reduction in arterial blood pressure, indicating renal vasodilation. 3. Pretreatment with methylprednisolone succinate prevents the fall in arterial blood pressure. 4. After pretreatment with atropine, renal blood flow falls in response to the reduction in arterial blood pressure, suggesting inhibition of cholinergic renal vasodilatation.
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Stinson et al. (1976) studied Coronary artery ligation. Pretreatment with methylprednisolone succinate or atropine prior to coronary artery ligation vs. Coronary artery ligation alone was evaluated on Renal vascular resistance and renal blood flow. In anaesthetized dogs, coronary artery ligation induces renal vasodilation, which is prevented by atropine pretreatment, suggesting inhibition of cholinergic renal vasodilatation.
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