Key result
Inositol trisphosphate (IP3) and Ca2+ are discussed as potential chemical transmitters of excitation-contraction coupling in skeletal muscle.
This review summarizes the mechanistic evidence for IP3 and Ca2+ as key chemical transmitters in skeletal muscle excitation-contraction coupling.
Suggests IP3 as possible EC coupling link in skeletal muscle; leaves open its physiological role.
The sarcoplasmic reticulum (SR) of skeletal muscle is an intracellular membranous network that controls the myoplasmic Ca2+ concentration and the contraction-relaxation cycle. Ca2+ release from the terminal cisternae (TC) region of the SR evokes contraction. How electrical depolarization of the transverse tubule is linked to Ca2+ release from the junctionally associated TC is still largely unknown. Independent evidence has been recently obtained indicating that either inositol trisphosphate (IP3) or (and) Ca2+ is (are) the chemical transmitter(s) of excitation-contraction coupling. Here we outline the experimental data in support of each transmitter and discuss possible interactive roles of Ca2+ and IP3.
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Volpe et al. (1986) conducted a review in Excitation-contraction coupling in skeletal muscle. Inositol 1,4,5-trisphosphate (IP3) and Ca2+ was evaluated. Inositol trisphosphate (IP3) and Ca2+ are discussed as potential chemical transmitters of excitation-contraction coupling in skeletal muscle.
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