Key result
Type 2 diabetes mellitus without obstructive coronary artery disease was associated with significantly lower resting myocardial transmural perfusion ratios compared to healthy controls (1.07 vs 1.14, p<0.001).
Why the study?
Does uncomplicated T2DM without obstructive CAD alter resting myocardial perfusion compared to healthy controls?
Observational (n=34)
No
Does uncomplicated T2DM without obstructive CAD alter resting myocardial perfusion compared to healthy controls?
Absolute Event Rate: 1.07% vs 1.14%
p-value: p=<0.001
Computed tomography myocardial perfusion imaging (CTP) can detect early resting myocardial perfusion impairments in uncomplicated T2DM patients before the onset of structural or functional cardiac abnormalities.
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Alerts to possible early perfusion changes in uncomplicated T2DM; leaves open whether CTP detects clinically relevant microvascular dysfunction.
Cai et al. (2018) conducted an observational in Type 2 diabetes mellitus without coronary artery disease (n=34). Type 2 diabetes mellitus vs. Healthy controls was evaluated on Overall transmural perfusion ratio (TPR) at rest (p=<0.001). Type 2 diabetes mellitus without obstructive coronary artery disease was associated with significantly lower resting myocardial transmural perfusion ratios compared to healthy controls (1.07 vs 1.14, p<0.001).
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