Key result
Type 2 diabetes was associated with more advanced subclinical impairment of diastolic function, including a higher E/e' ratio (13.3 vs 11.1, P<0.001), compared to non-diabetic obese controls.
Why the study?
Does type 2 diabetes independently worsen subclinical left ventricular diastolic function in obese patients compared to weight-matched non-diabetic controls?
Cross-Sectional (n=200)
Does type 2 diabetes independently worsen subclinical left ventricular diastolic function in obese patients compared to weight-matched non-diabetic controls?
Absolute Event Rate: 13.3% vs 11.1%
p-value: p=<0.001
Type 2 diabetes is associated with more advanced subclinical impairment of diastolic function and concentric hypertrophy independent of obesity.
Suggests diabetes-specific cardiomyopathy beyond obesity; leaves open need for prospective outcome studies before screening changes.
BACKGROUND: Subclinical left ventricular (LV) dysfunction is prevalent in type 2 diabetes (T2DM). As obesity has been proposed as one causal factor in the disease process, this could bias the reported prevalences. We wanted to characterize echocardiographic LV dysfunction in obese T2DM subjects as compared to non-diabetic obese controls. METHODS: One hundred patients with T2DM without clinical signs of heart failure (29% females, mean ± SD age 58.4 ± 10.5 years, body mass index (BMI) 30.1 ± 5.5 kg/m(2), blood pressure (BP) 141 ± 18/83 ± 9 mmHg) and 100 non-diabetic controls (29% females) matched for age (58.6 ± 10.5 years), BMI (29.8 ± 4.0 kg/m(2) and systolic BP (140 ± 14 mmHg) underwent echocardiography and color tissue Doppler imaging (TDI). Diastolic function was evaluated with conventional Doppler recordings and early (e') and late (a') myocardial velocities. The ratio between early transmitral filling (E) and the corresponding myocardial tissue velocity (e') served as an index of LV filling pressure. RESULTS: T2DM patients had more concentric hypertrophy with a relative wall thickness of 0.42 ± 0.07 vs controls 0.38 ± 0.07, P < 0.001. The T2DM group had signs of diastolic dysfunction with lower E/A ratio (0.91 ± 0.27 vs. 1.12 ± 0.38, P < 0.001), deceleration time (195 ± 49 vs 242 ± 72 ms, P < 0.001), e' (5.7 ± 2.0 vs. 6.6 ± 1.8 cm/s, P = 0.001), and a' (6.5 ± 2.0 vs. 7.6 ± 1.5 cm/s, P < 0.001) compared to the controls, and higher E/e' (13.3 ± 4.7 vs. 11.1 ± 3.5, P < 0.001). Thus, there were indications of pseudo normalization and increased filling pressure in the T2DM group, whereas the controls had evidence for relaxation abnormalities without elevated filling pressure. CONCLUSION: Compared to a non-diabetic obese group, more advanced subclinical impairment of diastolic function was seen in T2DM.
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Ofstad et al. (2014) conducted a cross-sectional in Type 2 diabetes (n=200). Type 2 diabetes vs. Non-diabetic weight-matched controls was evaluated on E/e' ratio (index of LV filling pressure) (p=<0.001). Type 2 diabetes was associated with more advanced subclinical impairment of diastolic function, including a higher E/e' ratio (13.3 vs 11.1, P<0.001), compared to non-diabetic obese controls.
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