Sequential pulsing during stellate ganglion stimulation caused a 60% incidence of ventricular fibrillation in dogs, independent of heart rate and blood pressure, but prevented by reserpine.
Does reserpine pretreatment prevent ventricular fibrillation induced by sympathetic stimulation and sequential pulsing in intact dogs?
Sympathetic stimulation increases ventricular vulnerability to fibrillation in a dog model, an effect that is independent of hemodynamic changes but preventable by catecholamine depletion with reserpine.
Sequential pulsing of the normal ventricle of intact dogs with twice threshold stimuli during stellate ganglion stimulation resulted in a 60% incidence of ventricular fibrillation (VF). The occurrence of VF was independent of accompanying changes in heart rate and arterial blood pressure. Reserpine pretreatment prevented the development of VF.
Verrier et al. (1974) studied this question. Sequential pulsing during stellate ganglion stimulation caused a 60% incidence of ventricular fibrillation in dogs, independent of heart rate and blood pressure, but prevented by reserpine.
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