Key result
Complex III enzymatic activity was lower in patients with idiopathic and ischemic dilated cardiomyopathy compared with normal controls, suggesting it is a secondary phenomenon.
Why the study?
Are mitochondrial respiratory chain enzyme activities altered as a primary or secondary phenomenon in patients with idiopathic dilated cardiomyopathy?
Population
17 patients with idiopathic dilated cardiomyopathy undergoing cardiac transplantation, 6 patients with…
Comparison
Assessment of mitochondrial respiratory chain… vs Ischemic dilated cardiomyopathy patients and…
Design
Case-control
Authors
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Lower complex III activity in IDC and IC vs donors; leaves open whether mitochondrial changes contribute to or result from cardiomyopathy.
Case-Control (n=40)
Are mitochondrial respiratory chain enzyme activities altered as a primary or secondary phenomenon in patients with idiopathic dilated cardiomyopathy?
The decrease in respiratory chain complex III activity in idiopathic dilated cardiomyopathy is likely a secondary phenomenon rather than a primary mitochondrial disease.
Diana Jarreta (2000) conducted a case-control in Idiopathic dilated cardiomyopathy (n=40). Idiopathic dilated cardiomyopathy vs. Ischemic dilated cardiomyopathy and normal organ donors was evaluated on Mitochondrial respiratory chain enzyme activities (complex III). Complex III enzymatic activity was lower in patients with idiopathic and ischemic dilated cardiomyopathy compared with normal controls, suggesting it is a secondary phenomenon.
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