Key result
Diabetic cardiomyopathy is a distinct clinical entity characterized by structural and functional myocardial abnormalities independent of coronary artery disease and hypertension.
This review highlights the existence and clinical implications of diabetic cardiomyopathy as a distinct pathophysiologic entity independent of coronary artery disease.
Diabetic cardiomyopathy may explain excess CV risk beyond CAD in diabetes; leaves open whether targeted interventions improve outcomes.
Cardiovascular disease is responsible for over 75% of deaths in diabetic patients, the majority caused by coronary artery disease (CAD) and heart failure. Cardiovascular morbidity and mortality in diabetic patients might be independently associated with other pathophysiologic mechanisms than coronary artery disease, epicardial and microvascular disease. There is an increasing notion that diabetic patients suffer from an additional cardiac condition named “diabetic cardiomyopathy”. There are several clinical, experimental, pathological and epidemiological researches that support the existence of a specific “diabetic cardiomyopathy”. This is assumed to be influenced by complex interaction of several metabolic changes that leads to both functional and structural alterations of the diabetic myocardium. In this review epidemiological aspects and clinical implications of this condition are presented.
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Mitevska et al. (2016) conducted a review in Diabetic cardiomyopathy. Diabetic cardiomyopathy is a distinct clinical entity characterized by structural and functional myocardial abnormalities independent of coronary artery disease and hypertension.
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