Key result
Adipocyte death contributes to the infiltration and activation of adipose tissue macrophages, inducing local chronic inflammation and systemic insulin resistance in obesity.
Adipocyte death plays a key role in obesity-related inflammation and systemic insulin resistance.
Should not change obesity management; leaves open therapeutic targeting of adipose inflammation pending trials.
Cell death is closely linked to many diseases including cancer, neurodegenerative diseases, autoimmune diseases, and metabolic disorders. Increased adipocyte death has been reported during the development of obesity. Adipocyte death may be caused by excessive stress during obesity-related adipose tissue remodeling. Adipose tissue macrophages are key players in obesity-related inflammation and systemic insulin resistance. Accumulating evidence suggests that adipocyte death is involved in immune cell function and initiates inflammation through an interaction with macrophages; however, the precise mechanisms remain largely unknown. This review focuses on the contribution of dead cells (particularly dead adipocytes in adipose tissue) to the pathophysiological conditions associated with obesity. J. Med. Invest. 64: 193-196, August, 2017.
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Kuroda et al. (2017) conducted a review in Obesity and obesity-related complications. Adipocyte death was evaluated. Adipocyte death contributes to the infiltration and activation of adipose tissue macrophages, inducing local chronic inflammation and systemic insulin resistance in obesity.
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