Key result
Inorganic nitrate supplementation of 300 to 800 mg per day supports cardiovascular health by lowering blood pressure, protecting the endothelium, and improving myocardial contractility.
Why the study?
Substantial reductions in NOS activity with aging can cause hypertension and cardiovascular complications, but NO can also be produced via the sequential reduction of inorganic nitrate.
Does inorganic nitrate supplementation provide cardioprotective benefits and compensate for declining NOS activity?
Does inorganic nitrate supplementation provide cardioprotective benefits and compensate for declining NOS activity?
Inorganic nitrate supplementation may offer a safe and efficacious strategy to maintain cardiovascular health by compensating for age-related or stress-induced declines in nitric oxide production.
May support nitrate use when NOS is impaired; hypothesis-generating and requires RCTs before clinical adoption.
Nitric oxide (NO) is continually produced by the enzyme nitric oxide synthase (NOS) and is essential to the control and effectiveness of the cardiovascular system. However, there is a substantial reduction in NOS activity with aging that can lead to the development of hypertension and other cardiovascular complications. Fortunately, NO can also be produced by the sequential reduction of inorganic nitrate to nitrite and then to NO. Nitric oxide from inorganic nitrate supplementation has been found to have the same cardioprotective benefits of NO produced by NOS. Moreover, it can effectively compensate for declining NOS activity due to aging or NOS inhibition by oxidative stress, hypoxia, or other factors. This review covers some of the major cardiovascular regulatory actions of NO and presents evidence that NO from inorganic nitrate supplementation can provide (1) compensation when NOS activity is inadequate, and (2) cardioprotective benefits beyond that provided by a healthy NOS system. In addition, it discusses how to obtain a safe and efficacious range of inorganic nitrate.
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John L. Ivy (2019) conducted a review in Cardiovascular disease. Inorganic nitrate supplementation was evaluated. Inorganic nitrate supplementation of 300 to 800 mg per day supports cardiovascular health by lowering blood pressure, protecting the endothelium, and improving myocardial contractility.
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