Randomized trial demonstrates an efficient synthesis of N-arylamidines in various substrates, suggesting broad applicability.
A one-step synthesis of monosubstituted N-arylamidinates via addition of amines to nitriles catalyzed by ytterbium amides is reported. The reactions with various substrates give the products in good to excellent yields with 5 mol % ytterbium at 100 degrees C under solvent-free conditions.
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Wang et al. (2008) studied this question.
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