Key result
High extracellular magnesium improves exercise-impaired vasomotor contraction and relaxation in preclinical models.
Why the study?
To observe the effect of magnesium ion on vascular function in rats after long-term exhaustive exercise.
Does magnesium ion improve vasomotor function in rats after long-term exhaustive exercise?
Does magnesium ion improve vasomotor function in rats after long-term exhaustive exercise?
Magnesium ions significantly improve vasomotor function and mitigate vascular damage in rats subjected to exhaustive exercise.
Answers are grounded in this paper and cite their sources.
High magnesium may aid vascular recovery in exercised rats; hypothesis-generating for human athletes, with no practice change warranted.
To observe the effect of magnesium ion on vascular function in rats after long-term exhaustive exercise. Forty male SD rats were divided into two groups, the control group (CON group, n = 20) and the exhaustive exercise group (EEE group, n = 20). Exhausted rats performed 1W adaptive swimming exercise (6 times/W, 15min/time), and then followed by 3W formal exhaustive exercise intervention. Hematoxylin and eosin (HE) staining was used to detect the morphological changes of rat thoracic aorta. The contents of interleukin-1 β (IL-1β) and tumor necrosis factor-α (TNF-α) in serum of rats were determined by enzyme-linked immunosorbent assay (ELISA), and the contents of malondialdehyde (MDA), reactive oxygen species (ROS), nitric oxide (NO) and endothelin 1 (ET-1) in serum of rats were determined by biochemical kit. Vascular ring test detects vascular function. Compared with the CON group, the smooth muscle layer of the EEE group became thicker, the cell arrangement was disordered, and the integrity of endothelial cells was destroyed; the serum Mg2+ in EEE group was decreased; the serum levels of IL-1β, TNF-α, MDA and ROS in EEE group were significantly higher than those in the CON group (P are all less than 0.05); the serum NO content in EEE group was significantly decreased, and the ratio of NO/ET-1 was significantly decreased. In the exhaustion group, the vasoconstriction response to KCl was increased, and the relaxation response to Ach was weakened, while 4.8mM Mg2+ could significantly improve this phenomenon (P are all less than 0.01). The damage of vascular morphology and function in rats after exhaustion exercise may be related to the significant increase of serum IL-1β, TNF-α, ROS, MDA and ET-1/NO ratio in rats after exhaustion exercise, while Mg2+ can significantly improve the vasomotor function of rats after exhaustion exercise.
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Wang et al. (2023) studied Exhaustive exercise-induced vascular dysfunction (n=40). High magnesium (4.8 mM) solution vs. Normal magnesium (1.2 mM) solution was evaluated on Vasomotor function (KCl-induced vasoconstriction and ACh-induced vasodilation) (p=<0.01). In rats subjected to exhaustive exercise, high extracellular magnesium (4.8 mM) significantly improved impaired vasomotor function, enhancing both KCl-induced contraction and acetylcholine-induced relaxation (p<0.01).
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