Answers are grounded in this paper and cite their sources.
A diverse 20-compound library of analogues based on the marine alkaloid oroidin were synthesized via a reductive acylation strategy. The final target was then assayed for inhibition and dispersion activity against common proteobacteria known to form biofilms. This methodology represents a significant improvement over the generality of known methods to acylate substrates containing 2-aminoimidazoles and has the potential to have broad application to the synthesis of more advanced oroidin family members and their corresponding analogues.
No takes yet. Share an insight, caveat, or question.
Ballard et al. (2009) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: