Key result
Latent cytomegalovirus infection in healthy adults was associated with a significantly increased frequency of autoantibodies to ribonucleoprotein compared to uninfected individuals (84% vs 24%).
Why the study?
Is cytomegalovirus (CMV) infection associated with an autoimmune response to U1 snRNP in healthy individuals and patients with SLE?
Cross-Sectional (n=174)
Yes
Is cytomegalovirus (CMV) infection associated with an autoimmune response to U1 snRNP in healthy individuals and patients with SLE?
Absolute Event Rate: 84% vs 24%
p-value: p=<0.0001
CMV infection may play a role in inducing autoimmune responses to U1 snRNP in a subset of patients with systemic lupus erythematosus.
No takes yet. Share an insight, caveat, or question.
May link latent CMV to autoantibody formation in healthy adults; hypothesis-generating and requires prospective confirmation.
Newkirk et al. (2001) conducted a cross-sectional in Healthy adults and patients with autoimmune diseases (SLE, MCTD) (n=174). Cytomegalovirus (CMV) infection vs. CMV seronegativity was evaluated on Presence of autoantibodies to ribonucleoprotein (RNP) (p=<0.0001). Latent cytomegalovirus infection in healthy adults was associated with a significantly increased frequency of autoantibodies to ribonucleoprotein compared to uninfected individuals (84% vs 24%).
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