This paper provides a review of anticoagulation therapy management, focusing on the emergency management of patients treated with vitamin K antagonists.
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VKA emergency management warrants protocol standardization; leaves open optimal reversal strategies in contemporary practice.
Vitamin K antagonists (VKA) are among the most widely prescribed drugs in the industrialized world. In fact, for decades, VKA have been the only orally available anticoagulant for the primary and secondary prevention of venous and arterial thrombotic events. Their efficacy has been widely demonstrated in a series of studies carried out in the 1990s. Since the incidences of atrial fibrillation and venous thromboembolism increase exponentially with age, the number of anticoagulated patients is destined to increase. This paper examines anticoagulation therapy management with particular attention to the use of VKA.
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Manzato et al. (2013) conducted a review in Patients treated with oral anticoagulants requiring emergency management (over-anticoagulation, bleeding, or urgent surgery). Emergency management strategies (Vitamin K, FFP, PCC, rFVIIa) was evaluated.
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