Key result
Omeprazole impaired ventricular remodeling in infarcted rats by reducing gastric vitamin C uptake, decreasing DDAH2 expression, and increasing myocardial ADMA compared with vehicle.
Why the study?
Proton pump inhibitors have been shown to increase the risk of myocardial infarction, but whether they adversely affect ventricular remodeling in infarcted rats remained unknown.
Does omeprazole impair ventricular remodeling in male Wistar rats with induced myocardial infarction?
RCT
randomly assigned
Does omeprazole impair ventricular remodeling in male Wistar rats with induced myocardial infarction?
Proton pump inhibitors like omeprazole may impair ventricular remodeling post-myocardial infarction by reducing gastric vitamin C uptake, an effect preventable by vitamin C or olmesartan coadministration.
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Omeprazole may impair post-MI remodeling in rats; leaves open clinical relevance and human translation.
Chen et al. (2019) conducted an RCT in myocardial infarction. omeprazole vs. vehicle was evaluated on ventricular remodeling. Omeprazole impaired ventricular remodeling in infarcted rats by reducing gastric vitamin C uptake, decreasing DDAH2 expression, and increasing myocardial ADMA compared with vehicle.
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