Key result
Anthracycline administration by 6-h infusion (n=71) showed no advantage over bolus injection (n=40) for late cardiotoxicity, with both groups exhibiting similar mild left ventricular impairment.
Why the study?
Does anthracycline administration by 6-hour infusion compared to bolus injection reduce late cardiotoxicity in children surviving acute lymphoblastic leukaemia?
Population
111 children who were relapse-free survivors of treatment for acute lymphoblastic leukaemia (ALL)
Comparison
Anthracycline administered by 6-hour infusion vs Anthracycline administered by bolus injection
Design
Cohort
Follow-up
5.3 +/- 2.0 years and 5.4 +/- 1.0 years
Authors
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Cardiac dysfunction occurs across anthracycline doses in childhood ALL survivors; leaves open whether infusion reduces late cardiotoxicity.
Cohort (n=111)
Does anthracycline administration by 6-hour infusion compared to bolus injection reduce late cardiotoxicity in children surviving acute lymphoblastic leukaemia?
Administering a modest cumulative dose of daunorubicin via 6-hour infusion rather than bolus injection does not prevent late subclinical left ventricular dysfunction in childhood leukemia survivors.
Levitt et al. (2004) conducted a cohort in Acute lymphoblastic leukaemia (n=111). Anthracycline administration by 6-h infusion vs. Anthracycline administration by bolus injection was evaluated on Cardiac performance assessed by echocardiography. Anthracycline administration by 6-h infusion (n=71) showed no advantage over bolus injection (n=40) for late cardiotoxicity, with both groups exhibiting similar mild left ventricular impairment.
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