Key result
Polydiacetylene micelles deliver LXR-agonists and upregulate target genes without disrupting lipid metabolism.
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studies showed that the nanohybrid micelles exhibited favorable pharmacokinetics/biodistribution and were able to upregulate, to some extent, LXR target genes with no alteration of lipid metabolism.
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Jamgotchian et al. (2023) studied this question. Polydiacetylene micelles delivering LXR-agonists exhibited favorable pharmacokinetics and upregulated LXR target genes without altering lipid metabolism.
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