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OBJECTIVES: Stimulant users smoke cigarettes at high rates; however, little is known about the relationship between tobacco and stimulants. METHODS: Our goal in this article is to synthesize a growing literature on the role of cigarette smoking in stimulant addiction. RESULTS: Early nicotine exposure may influence the development of stimulant addiction. Preclinical and clinical studies suggest a facilitatory role of nicotinic agonists for stimulant addiction. Smoking appears to be associated with more severe stimulant use and poorer treatment outcomes. CONCLUSIONS: It is important to assess smoking and smoking-related variables within stimulant research studies to more fully understand the comorbidity. Integrating smoking cessation into stimulant treatment may improve nicotine and stimulant treatment outcomes.
Weinberger et al. (Thu,) studied this question.