What is the clinical evidence from this study?

Study design: Cohort. Population: Gastrointestinal cancer (n=1326). Intervention: Preoperative sarcopenia vs. Non-sarcopenic patients. Primary outcome: 1-year mortality (HR 1.98, 95% CI 1.36 to 2.88, p=< 0.05).

December 23, 2015Journal of the American College of Surgeons

Inclusion of Sarcopenia Outperforms the Modified Frailty Index in Predicting 1-Year Mortality among 1,326 Patients Undergoing Gastrointestinal Surgery for a Malignant Indication

Q: What are the key findings of this study?

Preoperative sarcopenia was independently associated with increased 1-year mortality (HR 1.98; 95% CI 1.36-2.88) in patients undergoing gastrointestinal cancer surgery.

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Key result

Preoperative sarcopenia was independently associated with increased 1-year mortality (HR 1.98; 95% CI 1.36-2.88) in patients undergoing gastrointestinal cancer surgery.

Why the study?

Does a composite risk-score including sarcopenia outperform the modified Frailty Index in predicting 1-year mortality in patients undergoing gastrointestinal cancer surgery?

Population

1,326 patients undergoing hepatobiliary, pancreatic, or colorectal surgery for a malignant indication…

Comparison

A 28-point weighted composite… vs Modified Frailty Index and Eastern Cooperative…

Design

Cohort

Follow-up

1 year

Authors

SBStefan BuettnerErasmus MC Cancer Institute DWDoris WagnerMedical University of Graz YKYuhree KimUniversity of Colorado Anschutz Medical Campus

Discussion

Member takes

Implication

May aid preoperative mortality risk stratification in GI cancer surgery; leaves open need for prospective validation before clinical adoption.

Study Design

Type

Cohort (n=1,326)

Structured PICO

Does a composite risk-score including sarcopenia outperform the modified Frailty Index in predicting 1-year mortality in patients undergoing gastrointestinal cancer surgery?

Population

1,326 patients undergoing hepatobiliary, pancreatic, or colorectal surgery for a malignant indication, evaluated for preoperative sarcopenia and followed for 1 year.

Exposure

A 28-point weighted composite risk-stratification score combining preoperative sarcopenia (defined by psoas density) and clinical parameters (age, preoperative anemia).

Comparator

Modified Frailty Index and Eastern Cooperative Oncology Group (ECOG) performance score.

Outcome

1-year mortalityhard clinical

Main Result

Hazard Ratio: 1.98 (95% CI 1.36–2.88)

p-value: p=< 0.05

Cite This Study

Buettner et al. (2015) conducted a cohort in Gastrointestinal cancer (n=1,326). Preoperative sarcopenia vs. Non-sarcopenic patients was evaluated on 1-year mortality (HR 1.98, 95% CI 1.36 to 2.88, p=< 0.05). Preoperative sarcopenia was independently associated with increased 1-year mortality (HR 1.98; 95% CI 1.36-2.88) in patients undergoing gastrointestinal cancer surgery.

synapsesocial.com/papers/6a629fad7fd4bc433b96a369 https://doi.org/10.1016/j.jamcollsurg.2015.12.020

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Implication

May aid preoperative mortality risk stratification in GI cancer surgery; leaves open need for prospective validation before clinical adoption.

Inclusion of Sarcopenia Outperforms the Modified Frailty Index in Predicting 1-Year Mortality among 1,326 Patients Undergoing Gastrointestinal Surgery for a Malignant Indication

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Inclusion of Sarcopenia Outperforms the Modified Frailty Index in Predicting 1-Year Mortality among 1,326 Patients Undergoing Gastrointestinal Surgery for a Malignant Indication

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider