THE IMPACT OF IMPLANTED BIOMATERIAL TO THE MICROBIOME Does technology change human or we change technology?

Contemporary medicine is unimaginabile without biotechnological involvment in diagnostic and therapeutic purpouses, but sometimes the discovery and application of new materials go faster then the understanding and adoption of the knowledge about the consequences for our organism. Understanding of biological processes at the microscopycal and molecular level would lead to better integration of biomaterial with human body environment. The primary aim of this review was to evaluate the potential microbiological effect after biomaterial and implant insertions to oral microbiota. The secundary aim was to evaluate if such microbiological shift has any effect to surgical wound-healing, post-implant tissue reaction or rejection of implanted biomaterial. The third aim was to question previous results of similar reviews and studies regarding microbiological role in improving therapeutic responses after biomaterial implantation in dental medicine. A comprehensive systematic search via Web of Science, Scopus and PubMed databases was conducted. The data synthesis showed similar results among clinical studies and several reviews with ambiguous conclusions leaving numerous questions without straight answers. We hypothesized that relationship between host microbiome and biomaterial insertion is mutual, but within the limitations of this review, the interaction between host-oral microbiota and material inset remains uncharted territory.