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The accuracy of commercially available tests for COVID-19 in Brazil remains unclear. We aimed to perform a meta-analysis to describe the accuracy of available tests to detect COVID-19 in Brazil. We searched at the Brazilian Health Regulatory Agency (ANVISA) online platform to describe the pooled sensitivity (Se), specificity (Sp), diagnostic odds ratio (DOR) and summary receiver operating characteristic curves (SROC) for detection of IgM/IgG antibodies and for tests using naso/oropharyngeal swabs in the random-effects models. We identified 16 tests registered, mostly rapid-tests. Pooled diagnostic accuracy measures 95%CI were: (i) for IgM antibodies Se=82% 76-87; Sp=97% 96-98; DOR=168 92-305 and SROC=0.98 0.96-0.99; (ii) for IgG antibodies Se=97% 90-99; Sp=98% 97-99; DOR=1994 385-10334 and SROC=0.99 0.98-1.00; and (iii) for detection of SARS-CoV-2 by antigen or molecular assays in naso/oropharyngeal swabs Se=97% 85-99; Sp=99% 77-100; DOR=2649 30-233056 and SROC=0.99 0.98-1.00. These tests can be helpful for emergency testing during the COVID-19 pandemic in Brazil. However, it is important to highlight the high rate of false negative results from tests which detect SARS-CoV-2 IgM antibodies in the initial course of the disease and the scarce evidence-based validation results published in Brazil. Future studies addressing the diagnostic performance of tests for COVID-19 in the Brazilian population are urgently needed.
Castro et al. (Sun,) studied this question.