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The growing global burden of diabetes necessitates the development of glucose sensors that are not only reliable and sensitive but also cost-effective and amenable to point-of-care use. In this work, we report a non-enzymatic electrochemical glucose sensor based on laser-induced graphene (LIG), functionalized with zinc oxide (ZnO) and palladium (Pd) nanostructures. The ZnO nanostructures were systematically optimized on the LIG surface by varying electrochemical deposition parameters, including applied potential, temperature, and deposition time, to enhance the electrocatalytic oxidation of glucose in alkaline medium. Subsequent modification with Pd nanostructures further improved the electrocatalytic activity and sensitivity of the sensor. The performance of the LIG/ZnO/Pd sensor was investigated using chronoamperometric and cyclic voltammetric analysis in 0.1 M NaOH at an applied potential of 0.65 V. The sensor exhibited a wide dynamic range (2–10 mM; 10–24 mM) with a limit of detection of 130 μM, capturing hypo- and hyperglycemia conditions. Moreover, a sensitivity of 25.63 µA·mM−1·cm−2 was observed. Additionally, the sensor showcased selective response towards glucose in the presence of common interferents. These findings highlight the potential of the LIG/ZnO/Pd platform for integration into next-generation, non-enzymatic glucose monitoring systems for clinical and point-of-care applications.
Aviha et al. (Sun,) studied this question.