Incremental Prognostic Value of Cardiac MRI Feature Tracking and T1 Mapping in Arrhythmogenic Right Ventricular Cardiomyopathy

Figures

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  Figure 1:. Flowchart of patient inclusion and exclusion. ARVC = arrhythmogenic right ventricular cardiomyopathy, MOLLI = modified Look-Locker inversion recovery, VA = ventricular arrhythmias.

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  Figure 2:. Images of cardiac MRI biventricular global longitudinal peak strain (GLS) analysis and extracellular volume fraction (ECV) map. A 42-year-old female patient diagnosed with arrhythmogenic right ventricular cardiomyopathy based on the revised 2010 Task Force criteria who experienced sustained ventricular arrhythmias (VA) as a clinical end point during follow-up. (A) Left ventricular (LV) GLS (−12.97%) in long-axis planes (four-, three-, two-chamber view) and right ventricular (RV) GLS (−11.16%) in long-axis plane (four-chamber view). (B) Native T1, post-T1, and ECV (31.2%) map in the midventricular section of short-axis plane.

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  Figure 3:. Event-free survival of patients with arrhythmogenic right ventricular cardiomyopathy stratified by global longitudinal peak strain (GLS) and extracellular volume fraction (ECV). Kaplan–Meier event-free probability curves for sustained ventricular arrhythmias according to the median values for left ventricular (LV) GLS, right ventricular (RV) GLS, and ECV. Patients with (A) LV GLS greater than −15.6%, (B) RV GLS greater than −16.4%, and (C) ECV greater than 29.3% experienced a significantly higher rate of sustained VA (all P < .05).

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  Figure 4:. Receiver operating characteristic curves for predicting sustained ventricular arrhythmias at 5 years: incremental value of biventricular global longitudinal peak strain (GLS) and extracellular volume fraction (ECV) over arrhythmogenic right ventricular cardiomyopathy (ARVC) risk score. AUC = area under the receiver operating characteristic curve.