Key result
Renal denervation is a promising therapeutic approach for cardiorenal syndrome that reduces sympathetic nerve overactivity, leading to improved blood pressure control and decreased fluid retention.
Why the study?
The study aimed to investigate in more detail the therapeutic effects of renal denervation in addressing cardiorenal syndrome disorders, relying on experimental and human studies.
Does renal denervation improve outcomes in patients with cardiorenal syndrome?
Does renal denervation improve outcomes in patients with cardiorenal syndrome?
Renal denervation may be a promising therapeutic approach for managing cardiorenal syndrome by modulating renal sympathetic nerve over-activity and the renin-angiotensin system.
Renal denervation warrants evaluation in cardiorenal syndrome; leaves open efficacy confirmation in dedicated randomized trials.
: The "Cardiorenal Syndrome (CRS)" includes a simultaneous heart-kidney dysfunction in such a way that damage in one organ subsequently leads to damage in another and vice versa. Although for the first time in a classification in 2008, two main groups called cardiorenal and reno-cardiac (based on the onset of the disease in each organ) were used for this term, but today there are five main classifications for it. Various factors take part in this syndrome pathophysiology, including endotoxemia, inflammatory processes, metabolic derangements, infections, imbalance in neurohormones secretion, venous congestion and immunological dysfunction. But the main cause of this syndrome' onset in many cases is over-activity of renal sympathetic nerves and subsequently increased interaction with the stimulated renin-angiotensin system (both classical and non-classical axes). Regarding this fact, today renal denervation is known as a useful therapeutic approach in solving the disorders of this syndrome, which its safety and efficacy have been proven in many experimental and clinical studies. Respecting the above information, the aim of this study is to investigate the therapeutic effects of renal denervation in solving CRS disorders in more details, relying on the results of experimental and human studies in this field. The effects of using renin angiotensin blockers and other treatment methods for this syndrome have also been mentioned.
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Maneshian et al. (2023) conducted a review in Cardiorenal Syndrome. Renal denervation was evaluated. Renal denervation is a promising therapeutic approach for cardiorenal syndrome that reduces sympathetic nerve overactivity, leading to improved blood pressure control and decreased fluid retention.
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