Key result
Obese subjects with type 2 diabetes had lower glucose disposal (4.9 vs 7.5 mg/min/kg; P<0.001) and significantly lower expression of adipogenic genes including SREBP1c (P<0.01) than obese controls.
Population
67 obese individuals, including 42 with type 2 diabetes and 25 non-diabetic subjects matched for age and…
Design
Cross-sectional
Authors
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May link impaired adipogenesis to insulin resistance in obese T2D; hypothesis-generating, requiring longitudinal confirmation before clinical relevance.
Cross-Sectional (n=67)
p-value: p=<0.01
Obese subjects with type 2 diabetes exhibit decreased expression of specific adipogenic genes in subcutaneous adipose tissue, which may contribute to impaired adipogenesis, larger fat cells, and insulin resistance.
Dubois et al. (2006) conducted a cross-sectional in Obesity with type 2 diabetes (n=67). Type 2 diabetes vs. Non-diabetic obese controls was evaluated on Expression of adipogenic genes (SREBP1c, STAT5A, and PPARgamma2) (p=<0.01). Obese subjects with type 2 diabetes had lower glucose disposal (4.9 vs 7.5 mg/min/kg; P<0.001) and significantly lower expression of adipogenic genes including SREBP1c (P<0.01) than obese controls.
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