Key result
Nitric oxide reversibly decreased SERCA activity and Ca2+ uptake in rabbit skeletal muscle sarcoplasmic reticulum in a concentration-dependent manner, independent of the cGMP-PKG system.
Nitric oxide reversibly inhibits SERCA activity and Ca2+ uptake in rabbit skeletal muscle, likely via direct action on the SERCA protein.
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NO inhibition of skeletal SERCA may alter Ca handling; leaves open cardiac translation and in vivo relevance.
Ishii et al. (1998) studied this question. Nitric oxide was evaluated on SERCA activity and Ca2+ uptake. Nitric oxide reversibly decreased SERCA activity and Ca2+ uptake in rabbit skeletal muscle sarcoplasmic reticulum in a concentration-dependent manner, independent of the cGMP-PKG system.
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