Key result
Growth hormone treatment significantly increased red cell mass by 183 mL (P<0.006), plasma volume, and total blood volume in adults with growth hormone deficiency.
Why the study?
Does Growth Hormone improve red cell mass, plasma volume, and total blood volume in adults with Growth Hormone Deficiency?
Population
13 adult patients with Growth Hormone Deficiency (GHD)
Comparison
Growth Hormone (GH) 0.036 U/kg.day for 3 months vs Placebo
Design
RCT, double blind
Follow-up
3 months
Authors
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GH replacement increases RCM and TBV in adult GHD; confirms GH regulation of erythropoiesis and plasma volume in adults.
RCT (n=13)
Double-blind
Does Growth Hormone improve red cell mass, plasma volume, and total blood volume in adults with Growth Hormone Deficiency?
Mean Difference: 183
p-value: p=<0.006
Growth hormone replacement in adults with GH deficiency significantly stimulates erythropoiesis and increases plasma and total blood volume.
Christ et al. (1997) conducted an RCT in Growth hormone deficiency (n=13). Growth hormone (GH) vs. Placebo was evaluated on Change in red cell mass (RCM) (MD 183, p=<0.006). Growth hormone treatment significantly increased red cell mass by 183 mL (P<0.006), plasma volume, and total blood volume in adults with growth hormone deficiency.
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