Key result
In patients with high-grade carotid occlusive disease, retrograde ophthalmic artery flow was associated with chronic ocular ischaemic syndromes.
Why the study?
Does ophthalmic artery flow pattern after vasodilatory stimulus correlate with chronic ocular ischemia in patients with high-grade carotid occlusive disease?
Observational (n=45)
Does ophthalmic artery flow pattern after vasodilatory stimulus correlate with chronic ocular ischemia in patients with high-grade carotid occlusive disease?
Retrograde ophthalmic artery flow is associated with chronic ocular ischemic syndromes in patients with severe carotid occlusive disease.
May aid differentiation of ocular ischemia mechanisms in carotid disease; leaves open prospective validation before clinical use.
Ocular changes due to chronic ischaemia are described in 45 patients with hemodynamically significant carotid occlusive disease. Regarding the ophthalmic artery flow before and after vasodilatory stimulus, the patients were divided into four different groups. Eyes with permanent anterograde ophthalmic artery flow had evidence of embolic features, but no signs of chronic hypoperfusion. In the group where anterograde ophthalmic artery flow changed to retrograde after 1 g intravenous acetazolamide, the patients had symptoms of critical ocular perfusion, but only subtle structural changes could be demonstrated. Chronic ocular ischaemic syndromes were found in the cases with retrograde ophthalmic artery flow, especially where bilateral severe carotid obstruction was present.
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Kerty et al. (1995) conducted an observational in Hemodynamically significant carotid occlusive disease (n=45). Ophthalmic artery flow patterns and response to 1 g intravenous acetazolamide vs. Different flow pattern groups was evaluated on Ocular changes and chronic ocular ischaemia. In patients with high-grade carotid occlusive disease, retrograde ophthalmic artery flow was associated with chronic ocular ischaemic syndromes.
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