Key points are not available for this paper at this time.
A patient with akinetic mutism after surgical removal of a tumor from the anterior hypothalamus responded to treatment with lergotrile and bromocriptine (dopamine receptor agonists) but not to carbidopdl-DOPA or methylphenidate (presynaptic dopamine mimetics). His pharmacologic response was consistent with animal models of hypothalamic-induced akinetic states and suggests that akinesia may be related to loss of dopaminergic input to anterior cingulate cortex or related structures rather than to the striatum.
Ross et al. (Sun,) studied this question.