Silver‐Catalyzed Regio‐ and Stereoselective Thiocyanation of Haloalkynes: Access to (Z)‐Vinyl Thiocyanates

A regio‐ and stereoselective method for the preparation of ( Z )‐vinyl thiocyanate derivatives by silver‐catalyzed thiocyanation of haloalkynes is reported. This method features practical, free of ligand, broad substrate scope, excellent stereoselectivity and gram‐scale synthesis. Significantly, the halogen atom of haloalkynes is retained, which allows the synthesis of 2,5‐diphenylthiophene, thiazol‐2‐amine and trifluoromethyl sulfides derivatives via simple transformation. magnified image