Key result
High NT-proBNP levels (≥6096 ng/L) were associated with a significantly increased risk of in-hospital mortality compared to lower levels (HR 1.97) in unselected hospitalized adult patients.
Why the study?
Does a high NT-proBNP level predict in-hospital mortality in unselected hospitalized adult patients?
Observational (n=3,833)
No
Does a high NT-proBNP level predict in-hospital mortality in unselected hospitalized adult patients?
Hazard Ratio: 1.97 (95% CI 1.57–2.46)
Absolute Event Rate: 20.3% vs 6.5%
p-value: p=<0.001
High NT-proBNP levels are independently associated with increased in-hospital mortality and longer length of stay in unselected hospitalized adult patients.
High NT-proBNP was associated with increased in-hospital mortality; leaves open its incremental value for risk stratification.
OBJECTIVE: To compare in-hospital mortality in unselected adult patients according to N-terminal pro-brain natriuretic peptide (NT-proBNP) levels. METHOD: Retrospective study including 3833 adult patients (median age 72 years, 45% women) hospitalized between January 2013 and April 2015 in a Swiss university hospital, with at least one NT-proBNP level measurement during hospitalization. Patients were categorized in quintiles regarding their highest NT-proBNP level. In-hospital mortality and length of stay (LOS) were compared between the highest and the other quintiles. RESULTS: In-hospital mortality rate and LOS (average±standard deviation) were higher in the fifth quintile than in the others (6.5% vs 20.3%, and 20.8±24.0 vs. 14.9±26.5 days respectively, both p<0.001). After multivariate adjustment on age, gender, principal diagnoses, stage 5 renal failure and type of management, patients in the fifth quintile had a hazard ratio [95% confidence interval] of 1.97 [1.57-2.46] for in-hospital mortality and an adjusted LOS (average±standard error) of 20.4±1.0 vs. 14.9±0.5 days for the other quintiles (p<0.001). Further stratification on the main diagnosis at discharge led to similar findings. CONCLUSION: Patients with high levels of NT-proBNP are at higher risk of in-hospital mortality and longer LOS, regardless of their clinical characteristics. NT-proBNP level can be a helpful tool for predicting in-hospital patient outcome in unselected adult patients.
No takes yet. Share an insight, caveat, or question.
Benmachiche et al. (2018) conducted an observational in Unselected hospitalized patients (n=3,833). High NT-proBNP level (≥6096 ng/L) vs. Lower NT-proBNP levels (<6096 ng/L) was evaluated on In-hospital all-cause mortality (HR 1.97, 95% CI 1.57-2.46, p=<0.001). High NT-proBNP levels (≥6096 ng/L) were associated with a significantly increased risk of in-hospital mortality compared to lower levels (HR 1.97) in unselected hospitalized adult patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: