The Bunyamwera serogroup (family Bunyaviridae, genus bunyavirus) contains more than 20 serologically cross-reactive viruses, 7 of which have been isolated in North America.1 Cache Valley virus, first isolated in Utah in 1956,2 has been recovered mainly from mosquitoes (genera culiseta, aedes, and anopheles) and occasionally from vertebrates and has the widest apparent distribution among this serogroup of viruses. Antibodies against Cache Valley virus and other viruses of the Bunyamwera serogroup are prevalent in livestock, large wild mammals, and humans from Alaska to Argentina.3 An association between Cache Valley virus infections and congenital malformations (various musculoskeletal and central nervous system defects) . . .
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Sexton et al. (1997) studied this question.
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