Subjective experience of treatment, side‐effects, mental state and quality of life in chronic schizophrenic out‐patients treated with depot neuroleptics

Larsen EB, Gerlach J. Subjective experience of treatment, side‐effects, mental state and quality of life in chronic schizophrenic out‐patients treated with depot neuroleptics. Acta Psychiatr Scand 1996: 93: 381–388. © Munksgaard 1996. Attitude towards treatment, side‐effects, mental state and quality of life was assessed in 53 chronic schizophrenic out‐patients on maintenance treatment with depot neuroleptics. It was found that 60% of the patients viewed depot medication positively, while only 8% viewed it negatively. Only 70% of patients complained about side‐effects, even though 94% had scored as having them. Hypokinesia and hyperkinesis were the side‐effects least noticed by the patients, but most noticed by the treating physician, while the opposite was the case with psychic side‐effects. Only 49% of patients thought they had a psychotic illness, and there was no correlation between the patients' own evaluation of the severity of their illness and their score on the Positive and Negative Symptom Scale (PANSS) or the treating physician's evaluation. Quality of life did not correlate with either side‐effect score or PANSS score. The schizophrenic patients' assessment of their condition was therefore in general different both from that of the treating physician and from that determined using rating scales.